英國(guó)醫(yī)學(xué)研究委員會(huì)（MRC）2024年招聘博士后（NATA（核酸治療加速器））
英國(guó)醫(yī)學(xué)研究委員會(huì)，創(chuàng)建于1920年，系隸屬于教育與科學(xué)國(guó)務(wù)大臣的政府機(jī)構(gòu)。該委員會(huì)下設(shè)應(yīng)用心理學(xué)研究所、環(huán)境心理學(xué)研究所、塵肺研究所和毒理學(xué)研究所等機(jī)構(gòu)。全委員會(huì)共有成員4274人，其中研究人員2771人。
Postdoctoral Researcher – Biology
Employer
NATA
Location
Harwell, Didcot
Salary
£39,375-£41,843 per annum
Closing date
28 Jan 2024
Discipline
Biomedicine, Life Science
Job Type
Postdoctoral, Researcher
Employment - Hours
Full time
Duration
Permanent
Qualification
PhD
Sector
Charity/NGO
Postdoctoral Researcher – Biology
Harwell, Didcot
£39,375-£41,843 per annum (Depending on experience)
Permanent
Full time on-site – 36 hours per week
About us
The Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), has invested £30m over 4 years through the Strategic Priorities Fund to establish a Nucleic Acid Therapy Accelerator (NATA) that will support state-of-the-art interdisciplinary research to solve critical issues in nucleic acid drug development, through focused NATA research challenges and a NATA infrastructure hub.
NATA (https://www.natahub.org/) focuses on building internal chemistry, biology and operational capabilities while catalysing collaborative R&D activity to tackle significant barriers facing oligonucleotide therapy manufacturing and delivery. This investment will support capacity building in terms of equipment, upskilling and domain expertise that will be essential in developing critical mass to catalyse and de-risk the development of next-generation nucleic acid therapeutics.
About the Role
We are seeking to appoint a highly motivated and enthusiastic postgraduate scientist. The Biology Researcher will be critical in supporting the NATA biology department by developing new techniques and methods related to the assessment of delivery, toxicity and efficacy of nucleic acid therapeutics in multidisciplinary projects. This individual will be involved in the development of new techniques and methods for 1) the quantification and localization of nucleic acid therapeutics after administration in vitro and in vivo, 2) the mechanism of uptake of new nucleic acid therapeutic conjugates, 3) the assessment of clearance and pharmacokinetic parameters associated to nucleic acid therapeutics. They will report to the Head of Biology.
About You
You will have:
Hold a relevant Ph.D/D.Phil in biology, biochemistry pharmacology, toxicology or a related discipline
Peer-reviewed research publications commensurate with career stage
Experience of conventional and advanced cell culture approaches with cell lines / primary cells
Fluorescence/confocal microscopy and image analysis
Cell-based screening assays such as ELISA, luciferase, qPCR and western blotting
Key Responsibilities include:
Undertake laboratory experiments as required by the project and analyse/report data (presentations, verbal and written report)
Carry out target design, target screening, validation and toxicology assessment of nucleic acid therapeutics
Perform efficacy assessment using mRNA/protein quantification methods and functional assessments including immunofluorescence and confocal imaging
Research and establish new techniques and methods for quantification and localization of nucleic acid therapeutics after administration in vitro and in vivo
For the full job description, please visit our site.
Benefits:
Choosing to come to work at the MRC (part of UK Research and Innovation (UKRI)) means that you will have access to a whole host of benefits, from a defined-benefit pension scheme and excellent holiday entitlement, to access to employee shopping/travel discounts and a salary sacrifice cycle to work scheme. In addition, you will have the opportunity to contribute to the work of a world-class medical research organisation.
How to Apply:
For full details and to apply, please click apply to submit an application. Your cover letter should clearly outline how you fulfil the criteria listed in the personal specification and your motivation for applying for this role.
Please quote reference NATA 2321
The closing date for applications is Sunday 28th January 2024
