Introduction of the Director
Eric Westhof is a member of the French Academy of Sciences and the German Academy of Sciences (Leopoldina), a member of the European Molecular Biology Organization (EMBO), a member of the Association of Chinese and French Experts, a principal researcher at the Wenzhou Institute of the University of the Chinese Academy of Sciences (UCAS), a visiting professor at the Southwest University of China (SWU), a professor emeritus of the University of Strasbourg (UNIS), and the president of the French Society of Gutenberg Representative.
For his outstanding academic achievements, he has received several French and international awards, including the Jacques Monod Prize, the Charles Leopold Meyer Prize, the Distinguished Service Award of the RNA Society, the Fyodor Lynn Medal of the German Society for Biochemistry and Molecular Biology, the Wang Yingjian Medal of the Shanghai Institute of Biochemistry of the Chinese Academy of Sciences, and the Rolf Sammet Prize of the Johann Wolfgang Goethe University in Frankfurt, Datta Medal of the European Union of Biochemistry, and the Lifetime Achievement Award of the International RNA Society.
According to Web of Science, he has published 477 papers (32,760 citations with an h-index of 97),
Projects and Research
His research activities focus on the relationship between sequence, three-dimensional structure, evolution and function of RNA molecules. The goal is to understand RNA evolution and the ongoing interaction between sequence changes and RNA structure/activity. Through comparative crystallographic and bioinformatics approaches, he studied RNA folding and biological functions. To this end, he introduced the "Leontis-Westhof" RNA base pair nomenclature to annotate all types of base pairs in nucleic acids, and in 2010 he launched RNA-Puzzles, an international competition to evaluate blind predictions of 3D RNA structure. The project is part of an ongoing effort to extract maximum information from structure-anchored comparative sequence analysis. Because sequence alignment and 3D assembly of RNA modules have enabled me to predict large catalytic RNAs, such as those of group I introns and RNaseP, he hopes to continue my research along these lines. Indeed, RNA sequence alignments are extremely rich; they allow the identification of conserved helix lengths, unpaired regions, anchor points, conserved residues, semi-conserved residues, concatenated regions, RNA modules and conserved hairpins, conserved or exchanged non-Watson-Crick pairs, as well as key structural residues (e.g., U-turns). The project will include (1) development of methods and tools for generating structure comparisons, i.e., experimental structure-based comparisons, and (2) automation of the overall process.
Conditions for recruitment
1. Hold PhD in molecular chemistry, molecular biology, structural biology or bioinformatics;
2. Good reading and writing skills in English ;
3. Ability to work independently on a computer, and proficiency in at least one programming language;
4. Skills in molecular calculations or sequence alignments are advantageous.
Compensation
The postdoctoral students will be admitted to the postdoctoral mobile station of University of Chinese Academy of Sciences (UCAS), and the fresh graduates will enjoy the same policies as those of NUST, such as staying in Beijing and working place is in Wenzhou, and the outstanding ones can be recruited as the associate researcher of the subject group after leaving the station. The postdoctoral positions are divided into three categories (A, B and C), and the salaries are as follows:
A: 40W + tutor's allowance (0-18W) + performance incentive + five insurance and one gold.
B: 30W + mentor subsidy (0-12W) + performance incentives + five insurance and one pension
C: Negotiable mentor + performance incentive + five insurance and one gold
Talent apartment can be rented, about 1500RMB/month (Postdoctoral fellows who leave the station and stay to work in
Application
1. Please send a detailed CV in Chinese or English (photo, birthplace, education and work experience, list of achievements in scientific research with supporting documents, etc.).
2. Send the electronic version of the documents to eric@wiucas.ac.cn ou cl@wiucas.ac.cn
負(fù)責(zé)人介紹
埃里克·韋斯托夫（EricWesthof）是法國(guó)科學(xué)院院士，德國(guó)科學(xué)院院士，歐洲分子生物學(xué)組織（EMBO）成員，法國(guó)法中高級(jí)人才交流協(xié)會(huì)（AEFC）會(huì)員，國(guó)科溫州研究院首席研究員，西南大學(xué)客座教授，斯特拉斯堡大學(xué)名譽(yù)教授，法國(guó)古騰堡（Gutenberg）科學(xué)家聯(lián)盟執(zhí)行主席。
因其卓越的學(xué)術(shù)成就，他獲得了多個(gè)法國(guó)和國(guó)際獎(jiǎng)項(xiàng)，包括雅克·莫諾獎(jiǎng)、查爾斯-萊奧波德·邁耶獎(jiǎng)、RNA協(xié)會(huì)杰出服務(wù)獎(jiǎng)、德國(guó)生物化學(xué)和分子生物學(xué)協(xié)會(huì)費(fèi)奧多·林恩獎(jiǎng)?wù)�、中�?guó)科學(xué)院上海生物化學(xué)研究所王應(yīng)睞獎(jiǎng)、法蘭克福約翰·沃爾夫?qū)?middot;歌德大學(xué)羅爾夫·薩梅特獎(jiǎng)、歐洲生物化學(xué)聯(lián)合會(huì)達(dá)塔獎(jiǎng)?wù)乱约皣?guó)際RNA學(xué)會(huì)終身成就獎(jiǎng)。
根據(jù)WebofScience，他發(fā)表了477篇論文（32,760次引用，h指數(shù)為97），其中23篇在《自然》系列期刊上，11篇在《科學(xué)》上。他在2024年Research.com的生物學(xué)和生物化學(xué)領(lǐng)域科學(xué)家排名中位列全球第685位，法國(guó)第11位，并獲得生物學(xué)和生物化學(xué)領(lǐng)域領(lǐng)導(dǎo)者獎(jiǎng)。在2022年ScholarGPS全球高排名學(xué)者中，他在RNA領(lǐng)域排名第五。他合編了4本書(shū)，并擔(dān)任多個(gè)國(guó)際知名學(xué)術(shù)期刊的編輯委員會(huì)成員，包括《RNA》科學(xué)的副主編、牛津大學(xué)出版社《核酸研究》的執(zhí)行編輯、威利《分子識(shí)別雜志》的執(zhí)行編輯和愛(ài)思唯爾《生物化學(xué)和生物物理研究通訊》的執(zhí)行編輯。
項(xiàng)目與研究
他的研究集中在RNA分子的序列、三維結(jié)構(gòu)、進(jìn)化和功能之間的關(guān)系。目標(biāo)是理解RNA的進(jìn)化以及序列變化與RNA結(jié)構(gòu)/活性之間的持續(xù)互動(dòng)。通過(guò)比較晶體學(xué)和生物信息學(xué)的方法，他研究了RNA的折疊和生物功能。為此，他引入了“Leontis-Westhof”RNA堿基配對(duì)命名法，以注釋核酸中的所有類(lèi)型堿基對(duì)，并在2010年發(fā)起了RNA-Puzzles，這是一項(xiàng)評(píng)估3DRNA結(jié)構(gòu)盲預(yù)測(cè)的國(guó)際競(jìng)賽。該項(xiàng)目是從結(jié)構(gòu)錨定的比較序列分析中提取最大信息的持續(xù)努力的一部分。因?yàn)樾蛄斜葘?duì)和RNA模塊的3D組裝使他能夠預(yù)測(cè)大型催化RNA，如I組內(nèi)含子和RNaseP的RNA，他希望沿這些方向繼續(xù)研究。事實(shí)上，RNA序列比對(duì)極其豐富；它們?cè)试S識(shí)別保守的螺旋長(zhǎng)度、未配對(duì)區(qū)域、錨點(diǎn)、保守殘基、半保守殘基、協(xié)變區(qū)域、RNA模塊和保守發(fā)夾、非Watson-Crick配對(duì)的保守或交換，以及關(guān)鍵結(jié)構(gòu)殘基（如U型轉(zhuǎn)折）。項(xiàng)目將包括（1）開(kāi)發(fā)用于生成結(jié)構(gòu)比對(duì)的方法和工具，即基于實(shí)驗(yàn)結(jié)構(gòu)的比對(duì)；（2）整體過(guò)程的自動(dòng)化。
招聘條件
擁有分子化學(xué)、分子生物學(xué)、結(jié)構(gòu)生物學(xué)或生物信息學(xué)的博士學(xué)位；
良好的英語(yǔ)閱讀和寫(xiě)作能力；
具備良好的獨(dú)立電腦工作能力，掌握至少一種計(jì)算機(jī)語(yǔ)言；
具備分子計(jì)算或序列比對(duì)的能力者優(yōu)先。
薪酬
博士后：博后入中國(guó)科學(xué)院大學(xué)博士后流動(dòng)站，應(yīng)屆生享受?chē)?guó)科大留京戶(hù)口等同等政策，工作地點(diǎn)在溫州，出站后優(yōu)秀者可應(yīng)聘課題組副研究員。博士后分為三類(lèi)(A類(lèi)、B類(lèi)和C類(lèi))，薪資如下：
A：40W+導(dǎo)師補(bǔ)貼(0-18W)+績(jī)效獎(jiǎng)勵(lì)+五險(xiǎn)一金
B：30W+導(dǎo)師補(bǔ)貼(0-12W)+績(jī)效獎(jiǎng)勵(lì)+五險(xiǎn)一金
C：導(dǎo)師面議+績(jī)效獎(jiǎng)勵(lì)+五險(xiǎn)一金
可租住人才公寓，約1500元/月左右（博后出站留溫工作，可購(gòu)買(mǎi)6折人才房）
申請(qǐng)
1.請(qǐng)?zhí)峤恢形幕蛴⑽牡脑敿?xì)簡(jiǎn)歷（照片、出生地、教育和工作經(jīng)歷、科研成果清單及支持文件等）。
2.郵件主題命名為:"Name-Postdoctoral fellowship".將電子版文件發(fā)送至eric@wiucas.ac.cn或cl@wiucas.ac.cn，郵件主題命名為：“姓名-博士后招聘”
信息來(lái)源于網(wǎng)絡(luò)，如有變更請(qǐng)以原發(fā)布者為準(zhǔn)。
來(lái)源鏈接：
https://www.wiucas.ac.cn/recruitment/keyan/2024/2009.html
